A new paper uses intravital imaging to show that traumatic brain injury (TBI) results in ROS-dependent brain cell death.  Cell death is totally prevented by the provisioning of glutathione [which amazingly can penetrate across the skull bone], consistent with the ROS being essential for cell death.  The ROS source and ROS targets that mediate lethality remain unclear, but nonetheless suggest exciting parallels to the ferroptotic process we described recently.