Scott Dixon, Ph.D. ~ Principal Investigator
Scott was born in Ottawa, Canada. He completed a Ph.D. in medical genetics with Peter Roy studying worm neuromuscular development (University of Toronto, 2007). As a postdoc, he investigated yeast genetic interaction networks with Charlie Boone (University of Toronto, 2007-2008), and then cell death with Brent Stockwell (Columbia University, 2008-2013). Scott opened his lab at Stanford in 2014, and is an Assistant Professor in the Department of Biology. He is affiliated with the ChEM-H initiative, the Chemical/Biology Interface predoctoral training program, and the Cancer Biology Graduate Program. He currently teaches the undergraduate Biochemistry & Molecular Biology foundation course (BIO83) with Or Gozani and Judith Frydman. In the lab, Scott enjoys helping out a bit with every project. Outside the lab, Scott consults for biotech and pharmaceutical companies interested in cell death.
Leslie Magtanong, Ph.D. ~ Research Associate
Leslie obtained a B.Sc. in Biochemistry from Queen's University and a Ph.D. in Molecular and Medical Genetics from the University of Toronto. She joined the Dixon lab as a Research Associate following postdoctoral studies with Bill Jacobs at the Albert Einstein College of Medicine. In the Dixon lab, Leslie has investigated the regulation of ferroptosis by exogenous monounsaturated fatty acids, and co-authored our papers on p53 and ferroptosis, MRP1 and ferroptosis, and kinetic modulatory profiling, and also written a review on the role of lipid metabolism in non-apoptotic cell death. Leslie was the primary mentor for former Stanford undergrad Alexis Kahanu, now a medical school student at Tufts.
Joan Ritho, Ph.D. ~ Postdoctoral fellow
Joan obtained a B.Sc. in Biochemistry from Simpson College and completed her Ph.D. in Cancer Biology at the MD Anderson Cancer Center. The focus of her previous work was on the regulation of AMPK function by SUMO modification, and the involvement of complex II dysfunction in oxidative cancer cell death. Joan’s current interests center on how cancer cell growth and survival is regulated by changes in intracellular metabolism and protein post-translational modification.
Amy Tarangelo, B.Sc. ~ Graduate Student (Cancer Biology Program)
Amy holds a B.A. from the University of Pennsylvania with a double major in Biology and Visual Studies and, before enrolling at Stanford, worked studied the function of the tumor suppressor Rb in human and mouse cancer models. Amy's Ph.D. thesis project concerns the regulation of ferroptosis by the p53 pathway. Her work has won presentation prizes at the 2016 Stanford Cancer Biology retreat and the 2017 Fusion Cell Death and Metabolism meeting in Cancun, Mexico, and her first paper on p53 and ferroptosis was published in 2018. Amy also co-authored our study of monounsaturated fatty acids and ferroptosis, and a News & Views on iron and cancer cell death. Amy mentored Stanford VPUE undergrad Carson Poltorack (2016), SSRP summer student Myshal Morris (2017), and most recently our High School student Edo Biluar (2018). Amy has supported her work with a Graduate Fellowship from the National Science Foundation (NSF), an F31 predoctoral fellowship from the NIH/NCI and most recently a highly competitive F99/K00 award which will fund the remainder of her graduate studies and the first few years of her postdoctoral work.
Zintis Inde, B.Sc. ~ Graduate Student (Cancer Biology Program)
Zintis graduated from Brown University with a B.Sc. in Biology. Prior to joining the Cancer Biology Program at Stanford, Zintis worked for two years in the Greengard lab at Rockefeller University, studying the cellular and molecular features of depression. For his Ph.D. thesis, Zintis is studying cell death in response to metabolic perturbations at the single-cell level. Zintis was awarded a Graduate Fellowship from the National Science Foundation (NSF) to support his work in the the lab. His preliminary work won a presentation prize at the 2017 Stanford Cancer Biology retreat. In 2018, Zintis published a comprehensive review on the impact of non-genetic heterogeneity on drug-induced cancer cell death. In addition to his own experiments, Zintis has mentored Stanford undergrad and 2017 VPUE summer student Kyle Denton. Outside the lab, Zintis is past-president of the Stanford Biosciences Student Association (SBSA).
Giovanni Forcina, B.Sc. ~ Graduate Student (Biology, Chemical Biology Interface program), joint with Carolyn Bertozzi (Chemistry)
Giovanni completed his B.Sc. in Molecular Biophysics and Biochemistry at Yale University. As an undergraduate with Scott Strobel, Giovanni isolated and characterized a number of new fungal species and natural products from the Ecuadorian rainforest. He then worked as a technician in the Dixon laboratory for two years, and was first author on our study describing scalable time-lapse analysis of cell death kinetics, and co-first author on our recent kinetic modulatory profiling work. Gio then joined the Dixon and Bertozzi labs as a joint graduate student as part of the Department of Biology and also the Chemical/Biology Interface training program. As a Ph.D. student Gio is investigating the regulation of cell death by protein glycosylation. He is also a co-author on our study of monounsaturated fatty acids and ferroptosis, and a review of the role of GPX4 in ferroptosis. His work in the Dixon and Bertozzi labs is supported by a Stanford Graduate Fellowship (SGF) and a Graduate Fellowship from the National Science Foundation (NSF).
David Armenta, B.Sc. ~ Graduate Student (Biology)
David holds a B.A. in Molecular and Cellular Biology from Harvard. As an undergraduate researcher in Andrew Murray's lab he studied the impact of genetic instability on the evolution of S. cerevisiae. In 2015, as a summer intern at the Natural History Museum of London he helped transcribe the letter of the early evolutionary biologist Alfred Russell Wallace. For his Ph.D. thesis research he is interested in understanding the relationship between cancer cell nutrient uptake and survival, and was recently invited to given an oral presentation about his preliminary findings at the 2019 Fusion Cell Death, Cell Stress and Metabolism conference. David has also won Excellence in Teaching Awards in both 2018 and 2019, for his outstanding contributions as a teaching assistant in the Department.
Jason Rodencal, M.Sc. ~ Graduate Student (Cancer Biology)
Jason received a B.S. in Molecular Biology and a B.A. in Chemistry from the University of South Florida. He was awarded a Fulbright Fellowship in 2015 to study Cancer Cell and Molecular Biology at the University of Leicester in England, where he earned an M.Sc. In Leicester, Jason worked in the laboratory of Dr. Salvador Macip and conducted his thesis research on the impact of physiological oxygen tensions and reactive oxygen species on senescence induced by p53, p21, and p16. After completing his thesis, Jason worked as a Research Associate for one year in the laboratory of Dr. Elsa Flores at Moffitt Cancer Center, studying the role of TAp63-induced microRNA in cutaneous squamous cell carcinoma. For his Ph.D. thesis research, Jason is investigating the regulation of cell death by the p53 pathway.
Lauren Pope, B.Sc. ~ Graduate Student (Biology)
Lauren was a Centennial Scholar at James Madison University, where she earned her B.S. in Biology in 2017. While at JMU, she studied the biochemical structure and function of starch degrading enzymes in the model plant Arabidopsis. Lauren was a Summer Undergraduate Research Fellow for the American Society of Plant Biologists in 2017 and completed an internship at Corteva Agrisciences before starting graduate school at Stanford in 2018. Lauren’s Ph.D. thesis project concerns the regulation of non-apoptotic cell death, and this work is supported by an NSF Graduate Research Fellowship awarded in 2019.
Martha Kahlson, B.Sc. ~ Graduate Student (Biochemistry)
Martha received a B.A. in Biochemistry and graduated summa cum laude in Neuroscience from Mount Holyoke College in 2015. She conducted her thesis research in the laboratory of Dr. Kenneth Colodner, investigating how aging and tau dysfunction affect chaperone stress response in a D. melanogaster glial tauopathy model. Martha then worked as a research assistant at The Rockefeller University in the laboratory of Dr. Vanessa Ruta. She and Dr. Joel Butterwick worked towards elucidating features of the insect olfactory receptor Orco through biochemical, functional, and CryoEM structural studies. She started graduate school at Stanford in 2018. For her Ph.D. thesis research, Martha is investigating the regulation of cell death by protein acylation.
Julie Lee ~ Undergraduate Researcher
Julie is a sophomore with interest in protein biochemistry and cell death. She joined the Dixon lab as a B-SUPRS summer researcher in 2018 and has continued working in the lab into 2019. Her research focus is on the post-translational regulation of ferroptosis. She is mentored primarily by Giovanni Forcina.
Grace Mueller ~ Undergraduate Researcher
Grace is a rising junior majoring in biology with interests in the biochemical regulation of cell death. She joined the Dixon lab in 2019 as a BSURPS summer researcher and is mentored primarily by David Armenta and Leslie Magtanong.
The Dixon Lab is supported by the outstanding efforts of our shared administrative assistant, Janet Elder, and our shared Laboratory Technician, Marcela Gona-Nogueira.
Jennifer Cao, Ph.D. (2014-2018). Jen was the first postdoc to join the Dixon lab and her main paper on MRP1, glutathione and ferroptosis was published recently. Jen also co-authored our study of monounsaturated fatty acids and ferroptosis, and our scalable time-lapse analysis of cell death kinetics paper. Jen also published a review of ferroptosis and co-authored a study from the Carette lab at Stanford investigating the regulation of necroptosis. Additionally, Jen mentored Stanford undergrads Daisy McKim and Trevor Mileur, as well as Aunoy Poddar, a high school student and subsequent visiting summer student. Jen is currently a research scientist at the local biotech Forty Seven Inc.
Megan Conlon, Ph.D., Biology (2014-2018). Megan was the first graduate student to join the Dixon lab. Her project focused on kinetic modulatory profiling and the biochemical regulation of ferroptosis. Megan also published a commentary on ferroptosis in plants and co-authored our study describing scalable time-lapse analysis of cell death kinetics. During her time in the lab, Megan mentored Stanford undergrad Carson Poltorack and also filled various posts in the Stanford Bioscience Student Association and the Stanford Graduate Student Council. Megan is currently working as an application scientist at LI-COR Biosciences.
Pin-Joe Ko, Ph.D., Biology (2015-2019). Pin-Joe was the second graduate student to join the lab. His dissertation research concerning an unconventional form of nonapoptotic cell death regulated by a ZDHHC5-GOLGA7 protein acylation complex was recently published. Pin-Joe also co-authored our study of monounsaturated fatty acids and ferroptosis, and reviewed the connection between protein palmitoylation and cancer and more generally links between lipid metabolism in cell death. Pin-Joe won a poster prize at the 2016 CMB Research Symposium and his PhD thesis was awarded the 2019 Yanofsky Prize in Molecular Biology, given to the most outstanding graduate student in this field. Pin-Joe mentored our undergraduate student Claire Woodrow, and was recognized in 2019 by the Department for his many contributions to student life over the years.
Carson Poltorack, 2016 VPUE summer undergraduate, 2017 Biology Major grant, 2018 Bio-x summer undergraduate, Bio199 2016-2019, research assistant 2019. Carson’s senior thesis was awarded the Firestone Medal for Excellence in Undergraduate Research. His work investigating amino acid metabolism and cell death is published in preprint form.
Kyle Denton, 2017 VPUE summer undergraduate, Bio 199 2017, summer researcher 2018.
Claire Woodrow, 2016 VPUE summer student, Bio 199 2016-2018, summer researcher 2018. Claire co-authored our study of protein acylation and nonapoptotic cell death, having performed a number of the key protein structure-function experiments.
Myshal Morris, 2017 SSRP summer student from Langston University.
Trevor Mileur, ChEM-H undergraduate researcher 2016. Trevor co-authored our study linking MRP1 expression and glutathione efflux to ferroptosis sensitivity. Trevor did a lot of the CRISPR/Cas9 mutagenesis in this paper.
Andrew Chen, Bio 199 student 2015-2016.
Alex Wells, VPUE summer student 2014, Bio 199 student 2014-2016. Alex a co-author on our study describing scalable time-lapse analysis of cell death kinetics, and our kinetic modulatory profiling paper. Alex developed the entire computational pipeline making the analysis of data in both papers possible.
Alexis Kahanu, Bio 199 student 2014-2015, Bio-X summer student 2015. Alexis is a coauthor on our kinetic modulatory profiling paper.
Daisy McKim, Bio 199 student 2014-2015, VPUE summer student 2015.
Kristina Bassi, Summer student 2014.
High School Students:
Aunoy Poddar, Volunteer student 2014-2015. (Columbia University, Rabi Scholar). Aunoy is co-author on our paper about the regulation of ferroptosis by MRP1 and glutathione efflux. Aunoy did many of the Westerns for this paper.