An important question is how different cell death pathways interact with one another.  Caspase 3/7 can cleave PARP, for example, which might prevent PARP-mediated cell death (parthanatos).  In this paper, the Bogyo lab identifies an activity-based small molecule probe for caspase-1 and uses this to show that when caspase 1 activity is blocked, immune cells will still die, except now instead of dying via caspase 1-dependent pyroptosis, they die via classic caspase 3/7-medaited apoptosis.  Clearly there is much redundancy in the cell death networks of the cell, as might be expected for such an important process.