I enjoy papers that combine insights from multiple experimental models and systems. In this paper Giorgini's group first screens for suppressors of mutant Huntington protein (Htt)-induced cell death in yeast using a genome-wide ORF library, then validate hits in mammalian cell culture and Drosophila neuronal models. They identify a conserved role for glutathione peroxidases (GPXs) - important antioxidant enzymes - as inhibitors of Htt-induced pathology. These results support the notion that ROS are important for Htt-induced neuronal pathology. Again, however, the issue of cell-type specificity in vivo remains mysterious. Why is mutant Htt expression only lethal to a subset of neurons?