I enjoy papers that combine insights from multiple experimental models and systems.  In this paper Giorgini's group first screens for suppressors of mutant Huntington protein (Htt)-induced cell death in yeast using a genome-wide ORF library, then validate hits in mammalian cell culture and Drosophila neuronal models.  They identify a conserved role for glutathione peroxidases (GPXs)  - important antioxidant enzymes - as inhibitors of Htt-induced pathology.  These results support the notion that ROS are important for Htt-induced neuronal pathology.  Again, however, the issue of cell-type specificity in vivo remains mysterious.  Why is mutant Htt expression only lethal to a subset of neurons?