A few years ago Zach Schafer was lead author on a paper showing that detachment of mammary cells from the ECM resulted in oxidative cell death that could be prevented by antioxidants. Cell death here did not involve ferroptosis (as we thought it might for awhile). Rather, ROS inhibited fatty acid beta-oxidation in the mitochondria and this resulted in a lethal drop in ATP levels in the cell. Now, Zach's lab has shown that this mechanism is active in tumors formed in mice and that the expression of SOD and catalase is essential to prevent the death of these cells. Yet another rationale for targeting the redox networks of cancer cells.