Huge advance from Tony Pawson's lab in our understanding of signaling dynamics downstream of receptor tyrosine kinase activation.  They use scheduled multiple reaction monitoring to define how the composition of a signaling complex nucleated by the Shc1 adapter protein changes over time, directing different outputs downstream of EGF receptor activation.  Makes me nostalgic: my first graduate project concerned a related protein, FRS3.  Also was very fortunate to have Tony as one of my thesis committee members back in Toronto.