The kinase PINK1 and the E3 ubiquitin ligase Parkin are mutated in some forms of Parkinson's disease and it has been of interest to understand how these genes function to prevent neurodegeneration. One hypothesis is that these proteins control the targeted degradation of dysfunctional (i.e. likely ROS-overproducing) mitochondria via mitophagy. Now Richard Youle's lab at the NIH has performed a really beautiful and well-controlled set of genome-wide, high-content RNAi screens to find new modulators of Parkin mitochondrial translocation, including TOMM7, HSPA1L and BAG4. A good illustration of the power of high-content screening.