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Erastin somehow inhibits the function of the system xc- cystine/glutamate transporter. This in turn results in the depletion of intracellular cysteine. Cysteine is rate-limiting for the synthesis of reduced glutathione (GSH), a key intracellular antioxidant molecule. Thus, inhibition of system xc- eventually leads to the depletion of GSH and the iron-dependent accumulation of toxic lipid ROS. http://www.dixonlaboratory.com/contactinfo daily 0.75 2019-01-17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1518818439927-XUT7KUAENU3H3279174B/death_cell.jpg Lab News https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1547698116779-Q1DEB1YFQRMG9XKM6OU2/IMG_5716.jpg Lab News - David wins the raffle 15 Dec 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1547698052242-8UA3CG80WOQDBNUPBSYA/IMG_5714.jpg Lab News - Lab holiday party spread. 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Congrats to David! 2 November 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1542758136538-87CWQQ35P1ZPLFE04MNW/Image+11-20-18+at+6.55+PM.jpg Lab News - Brent Stockwell and Scott have a new review on ferroptosis published online today! 24 October 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1542757844124-YH2J5B0JW6Z8ELPAKGLK/00.Image+11-20-18+at+6.47+PM.jpeg Lab News - Our review on protein palmitoylation and cancer is published! Congrats to Pin-Joe! 25 September 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1539014715380-1JWJAV38SPQ1IPRMRVD7/IMG_4958.JPG Lab News - Biology retreat 2018. Deer at sunset. 21 September 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1539014529464-PHEXY5KW82WEVRTM89FB/IMG_4981.JPG Lab News - Biology retreat 2018. Our next speaker works on mice… 21 September 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1539014399895-IDTLDR122IWZUC2DTS9A/IMG_4923.JPG Lab News - Megan celebrates completing her oral Ph.D. thesis defense! Holding her new power crystal, a gift from the lab. 13 September 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1539014308712-2I8N66HA1GKCNUVB5R3C/IMG_4838.JPG Lab News - Dixon lab summer 2018 - keeping Dar Bar in business (or putting them out of it, if we are hungry) 27 August 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1539014271663-V0DCE91GQCQ1K9PJ8HCD/IMG_4836.JPG Lab News - We’ll miss our 4 great summer undergrads! 27 August 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1539013867664-TL8HFXY4H0VJJVP7XN2A/34.+JuliePoster.jpg Lab News - Julie Lee discussing her summer research at the SURP poster session 22 August 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1539014123470-7O5MUMXF5JGNN8EP0PKD/33b.Carson_Poster.JPG Lab News - Carson presents his work at the Bio-X summer symposium 22 August 2018 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1532815474127-2P5GNK5OQZMGBALNWGNT/33.Vert.jpg Lab News - Members of the lab go vertical at Great America; Scott becomes ill just watching this 27 July 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1530034016567-C7RIV0QCAZFH3LIUZG6I/32.Gio_retreat.jpg Lab News - Gio talking cell death at the ChEM-H retreat 26 Jun 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1530033955498-VFOANKVKDNA3L0Y3ZRTD/31.Amy.jpg Lab News - Amy discussing her work at the ChEM-H retreat 26 Jun 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1526784605814-FAGPB7VVDHSUQMTSTUTA/30.Lab.jpg Lab News - First look at our beautiful new lab space in the Bass building. 19 May 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1530034133205-9VYKGI1PT42QIRQTG3LN/30._b_commentary.jpeg Lab News - Our commentary on the Cell Reports paper is published in Oncotarget! Congrats to Amy! 15 May 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1524953071892-3IXBZS63GS26RC1IPHLC/28.CarsonASURPS.jpg Lab News - Carson enticing prospective students to Stanford with visions of participating in cutting edge cell death research 28 Apr 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1524953017189-5NQEDPGFGGI1DPHZTNOU/27.BioBBQ.jpg Lab News - A portion of the Dixon lab (in regular attire) enjoying the Biology picnic 20 Apr 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1520274301732-LLZCKGR1XO6VSTDMNOXL/26.Recruitement.jpg Lab News - Gio and Pin-Joe explain why cell death is awesome to potential future graduate students 1 Mar 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1518818036472-E0MV882TB0CCMF8GYEZC/24.+Listing.jpeg Lab News - 16 Feb 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1518401867226-XH9IMHZA0AO5KZY30MTX/23.Amsterdam.jpg Lab News - Passing over a canal on the way to the EACR Cell Death Meeting. Amsterdam, NL, 1 Feb 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1516742343935-6CYELRBAI9UZHKZW4IA6/22.+CDD_2018.jpeg Lab News - The latest nomenclature recommendations by Lorenzo Galluzzi and ~200 other authors in the cell death field is published! 23 Jan 2018 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1516383616890-XF0NDXHG6VO8C69J3A8Y/21.Cover.jpeg Lab News - Amy's art gets the cover 19 Jan 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1516383369363-P7NS2004GX44TR10Y814/20.AmyPaper.jpeg Lab News - Our paper on the p53 pathway and ferroptosis is published! Congrats to Amy and Leslie! 19 Jan 18 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1513615975287-KJHKXWSBNDS65X1SWEER/19.+ZintisReview.jpeg Lab News - Our review on cell death is published! Congrats to Zintis! 18 Dec 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1513615893167-BNB1LFJPNBIYQJRYP5AF/18a_Pillow.jpg Lab News - STACK-themed pillows. Coming soon to a home near you 16 Dec 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1513615804488-69U94ATUI4ZLXFHEOM6O/18b_SecretSanta.jpg Lab News - "White Elephant" gift exchange at the Dixon lab holiday party is no holds barred 16 Dec 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1509723979067-QFC0HBWZLN7AX08971YZ/12.+RO1_jpg.jpg Lab News - Grateful to the Damon Runyon Foundation and Andy Rachleff! Two additional years of funding for our work on cancer cell death. 2 November 2017 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1508168584729-W8XSMHEH2QXB4Y2B2Z2J/17.Gio.jpg Lab News - Gio successfully completes his qualification exam 9 Oct 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1508535892940-1H8DC9F58B3AV3FNFI7P/18.+Cell_review.jpeg Lab News - Cell 'Primer' on ferroptosis in published! Co-authored by Scott and other researchers in this emerging area. 5 Oct 2017 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1505630544829-L0NVHOW2M8OUGQMR6BCV/14.+Zintis.JPG Lab News - Zintis presents his work Stanford Cancer Biology Retreat, San Jose, 16 Sep 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1505540408858-FCQSZNSIZ96B920K1TLW/13.Amy_retreat.JPG Lab News - Amy presents her poster Stanford Cancer Biology Retreat, San Jose, 15 Sep 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1505422192366-U9TQ2EG50Z53VXCBIFEH/12.+RO1_jpg.jpg Lab News - Grateful to the NIH/NIGMS. New RO1 starts today! 14 Sep 2017 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504740717830-9KGR9FK50EXM9BSRF0T7/CCB_6+Sep.jpg Lab News - We are excited to join with our colleagues in launching the Stanford Center for Cell Biology Website here! https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504557308065-LD7RDVKXY0JKIT3HGUPS/BBB_1Sep17.JPG Lab News - Construction continues on our future home, the BBB (Bass Biology Building). Projected occupation in August 2018! Stanford campus, 1 Sep 2017 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504553818194-FK3QG67TAYH8ABRNX9XC/KylePoster.JPG Lab News - VPUE summer student Kyle Denton presents his summary poster Stanford campus, 31 Aug 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504554060632-8A7M2VBAVC39OP40NT1R/CampusRabbit.JPG Lab News - It's not all about birds. Campus also crawling with hare Stanford campus, 24 Aug 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504553753640-OJ75Y0VQ0ANLGKMF1VT9/Myshal+Talk.JPG Lab News - SSRP summer student Myshal Morris gives his final talk Stanford campus, 23 Aug 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504553646707-FIAFE48BFZ2COXTIJG26/GoldenEagle.JPG Lab News - A golden eagle carts away a squirrel. Biology on campus! Next to the parking circle of all places, Stanford campus, 21 Aug 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504553576534-FP2GW9XVUEGG18RYYZBF/Egret.JPG Lab News - Early bird spots the...egret (I think) CSHL Cell Death Meeting, 19 Aug 17 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504553363396-D86O2UCZPV3GPU77A489/MeganCSHL.JPG Lab News - Megan talks about her findings CSHL Cell Death Meeting, 18 Aug 2017 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504553307262-J5CX0SVPB7ZRV64C8B68/Pin-Joe+CSHL.JPG Lab News - Pin-Joe describes his latest results CSHL Cell Death Meeting, 16 Aug 2017 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504553255309-ARF7VTTKWU61A2N797XG/JenCSHL.JPG Lab News - Jen explains her work. Aunoy looks on. CSHL Cell Death Meeting, 16 Aug 2017 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1504552929903-SHMMDNW8XQ5F6CSQTN45/GelCookie.JPG Lab News - A gel cookie. Sample #3 looks correct. Spotted in the lab, May 26, 2017 http://www.dixonlaboratory.com/project-2 daily 0.75 2014-11-04 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1416006087463-F9C2JLBWOTNJN8VK3PNN/G5_f_2.png Project 2 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1415138560561-GHCFLC34BXDUVROFMJ83/image-asset.png Project 2 http://www.dixonlaboratory.com/lab-photos daily 0.75 2016-01-23 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1428971483418-9IQBPRGT4HZNUELM189J/Hoover+copy.jpg Lab & Campus Photos! https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1428971827036-FPV01B6D4169LCDIMZ17/image-asset.jpeg Lab & Campus Photos! Sunrise on Palm Drive https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1429376184124-3HYZPAGGH3FSZKCA4RIT/image-asset.png Lab & Campus Photos! Dixon lab bicycle posse on the way to a lab lunch https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1435557437767-DRBSXB88RDF5PWRJRKDX/image-asset.jpeg Lab & Campus Photos! Summer Scamper 5K 2015. Alexis, Anthony (friend of the lab), Alex, Gio, Leslie, Pin-Joe, Amy & Zintis representing the Dixon lab! https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1449879487193-T2CKM04AA2EC1CMZ4ZG6/ZintisQual.JPG Lab & Campus Photos! Celebrating Zintis' Ph.D. qualifying exam, December 2015. (L-R): Jen, Frederique, Amy, Pin-Joe, Zintis, Giovanni, Leslie, Jim and Megan. http://www.dixonlaboratory.com/contact-info daily 0.75 2025-12-05 https://images.squarespace-cdn.com/content/v1/51a7507be4b0434836e36d00/1542148072540-XHHA4LO9A7G829A9J9B5/IMG_5495.JPG Contact http://www.dixonlaboratory.com/read-me-alex daily 0.75 2025-05-12 https://images.squarespace-cdn.com/content/v1/53d7e714e4b0cb1125a8185a/1408049628553-DI4M8C71OPT845LWBJZI/img_0843.jpg Read Me https://images.squarespace-cdn.com/content/v1/53d7e714e4b0cb1125a8185a/1408051089601-1FGOGC94AFH3382KHIDS/image-asset.png Read Me https://images.squarespace-cdn.com/content/v1/53d7e714e4b0cb1125a8185a/1408051210145-TJZIWROSOKJNXSL492HI/image-asset.png Read Me